The drug Tretinoin-20 is used to treat severe acne that does not improve with other therapies, such as antibiotics. The pharmaceutical business Zen Labs produces this item, which has Isotretinoin as its active ingredient.
The synthesis of 13-cis-retinoic acid (isotretinoin) began in 1955. Rosacea, perioral dermatitis, seborrheic dermatitis, folliculitis, granuloma annulus, sarcoidosis, various keratinization disorders, and photo-aging are indications for the use of the drug in addition to acne.
Effect and benefits:
Isotretinoin slows down sebum gland duct epithelial cell growth, detritus generation, and makes it easier for detritus to be expelled and normalises the differentiation of terminal cells. Isotretinoin promotes secretion and lessens the production of sebum.
When taken orally, Isotretinoin has uneven absorption and limited bioavailability, however, when taken with meals, bioavailability increases by two times.
Within two to four hours, the blood plasma reaches its maximal concentration. 99.9% of the time, Isotretinoin binds to plasma proteins (mainly with albumin). Isotretinoin has a half-life of 19 hours. Isotretinoin is roughly equally eliminated by the kidneys and bile.
Recommended dosage and duration of use:
Zen Labs’ Isotretinoin is ingested orally. The dosing plan is customised for each individual because Isotretinoin’s side effects and therapeutic effectiveness are dose- and patient-dependent.
The drug is used for 16 to 24 weeks, the starting dose is 0.4 to 0.5 mg / kg per day, divided into two halves. It is taken with meals. Dose adjustment is carried out based on the seriousness of side effects and treatment response.
The drug is discontinued if, after 16 to 24 weeks, there has been a 70% reduction in the number of rashes. Upon proof of a recurrent or persistent course of the disease with an interval of at least two months, a repeated course of treatment is administered.
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